|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Odds ratio showed that lower levels of adiponectin and higher levels of resistin, but not of other cytokines, increased the risk of developing type 2 diabetes mellitus.
|
31811995 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies indicate a paradoxical relationship between adiponectin and cardiovascular mortality across many clinical settings including type 2 diabetes.
|
31805941 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The biomarker score that comprised of four biomarkers (TG-to-HDL ratio, ALT, ferritin, and adiponectin) was positively associated with T2DM risk (<i>P</i> trend <0.001).
|
31769241 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The recessive model of the ADIPOQ polymorphism rs822396 was significantly shown to confer a 3.63-fold risk towards type 2 diabetes after adjusting for confounding factors and Bonferroni correction [odds ratio (OR): 3.63 (1.20-10.96), p = 0.022]. rs1501299 gave a 3.82-fold risk towards development of T2DM but was not statistically significant after Bonferroni correction [OR: 3.82 (1.16-12.55), p = 0.027].
|
31755094 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, adiponectin reversed the effects of insulin resistance via AMPK α1, which provides a novel insight into the protective mechanism of adiponectin and may be used as a new strategy for the treatment of type 2 diabetes.
|
31693217 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this 10-year prospective study, NGT with higher serum RBP4 and PAI-1, and with lower adiponectin were associated with new-onset prediabetes and type 2 diabetes.
|
31690939 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
There was a positive association between blood adiponectin and ALMBMI in postmenopausal women without T2DM, but no association in those with T2DM.
|
31688578 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
This suggests that treatment of adiponectin effectively improves testicular functions by increasing expression of insulin receptor-mediated increased transport of energy substrate (glucose and lactate) and a marked reduction in oxidative stress are the possible mechanism by which adiponectin effectively improves testicular function in T2D mice.
|
31676315 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Plasma levels of Ad are reduced in obesity, which contributes to type 2 diabetes.
|
31629112 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The goal of the study was to assess associations of rs17300539, rs266729, rs182052, rs2241766, and rs17366743 single nucleotide polymorphisms (SNPs) of the <i>ADIPOQ</i> gene with concentrations of serum adiponectin and with coronary atherosclerosis and type 2 diabetes mellitus in 447 patients (316 men and 131 women) subjected to coronary angiography.
|
31561637 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Future studies can use these methods to examine insulin, adiponectin, and leptin metabolic dysregulation in aging and disease states, such as type 2 diabetes and Alzheimer's disease-related dementias.
|
31539648 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
We explored the effects of Roux-en-Y gastric bypass (RYGB) on the circulating levels of adiponectin, leptin, and the adiponectin/leptin (Adpn/Lep) ratio in patients with obesity and type 2 diabetes (T2D).
|
31484347 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
There was a positive association between blood adiponectin and ALMBMI in postmenopausal women without T2DM, but no association in those with T2DM.
|
31461078 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate adiponectin and 8-OHdG amongst elderly patients with T2DM and to determine the role of adiponectin and 8-OHdG in the cognitive impairment of the elderly patients with T2DM.
|
31424368 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Ten randomized controlled trials (RCTs), that evaluated the effects of SGLT2 inhibitors on blood leptin and adiponectin levels in patients with type 2 diabetes, were identified by performing a systematic search of Pubmed, Embase, Cochrane, and Web of science databases through July 2018.
|
31408894 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the effect of zinc supplementation on glycemic control, and the potential mediating role of adiponectin, in patients with type 2 diabetes.
|
31345359 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results of the meta-analysis did not show significant differences (<i>p</i> > 0.05) between low GI and higher GI diets with respect to adiponectin and C-reactive proteins in patients with type 2 diabetes, but a significant difference (<i>p</i> < 0.001) was observed between the two groups in relation to interleukin-6.
|
31336986 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
We assessed if there is a difference in IR and metabolic syndrome components between glimepiride and glibenclamide treatment as well as adiponectin concentration in T2DM.
|
31292311 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Association of Low Serum Adiponectin Levels with Aortic Arterial Stiffness in Patients with Type 2 Diabetes.
|
31234308 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we not only discuss the favorable adipokines like adiponectin, omentin, C1q tumor necrosis factor-related proteins, but also unfavorable ones like resisitin and visfatin, in the aim of finding potential biomarkers recommended for the clinical use in the diagnosis, prognosis and follow up of patients with T2D at high risk of developing cardiovascular diseases as well as leading to new therapeutic approaches.
|
31229411 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Scoring of peripheral vascular calcification and peripheral arterial occlusive disease, using CT-scan and color-duplex ultrasonography respectively, were conducted and explored in relation to serum adiponectin level in a cross sectional study of 197 patients with type 2 diabetes.
|
31168327 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Male gender and history of both gestational and type 2 diabetes were associated with significantly lower total adiponectin levels (p < 0.05).
|
31159801 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate gene-environment interactions among moderate/severe periodontitis, polymorphisms of adiponectin (ADIPOQ)-rs1501299, and leptin receptor (LEPR)-rs1137100 on T2DM risk in Chinese subjects.
|
31128439 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this pilot study was to explore relations between biomarkers of Cd, Pb and Hg exposure, early urinary biomarkers of renal dysfunction (kidney-injured molecule-1 (KIM-1), N-acetylglucosaminidase and retinol-binding protein (RBP)) and plasma biomarkers deemed predictive of the risk of developing T2D (adiponectin, leptin, branched-chain and aromatic amino acids), among 70 participants (age range: (46-87 yrs)) from the Canadian Longitudinal Study on Aging (CLSA) with normal glycemic control (glycated haemoglobin ≤ 6.5%) in all but four of them.
|
31100493 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
CTRP3 was independently associated with HOMA-IR (r = -0.327, p < 0.05) and adiponectin (r = 0.436, p < 0.01) in T2DM group.
|
31009504 |
2019 |